Neutrophil Extracellular Traps Induce Brain Edema Around Intracerebral Hematoma via ERK-Mediated Regulation of MMP9 and AQP4

中性粒细胞胞外诱捕网通过ERK调节MMP9和AQP4诱导脑内血肿周围脑水肿

Perihematomal edema (PHE) significantly aggravates secondary brain injury in patients with intracerebral hemorrhage (ICH), yet its detailed mechanisms remain elusive. Neutrophil extracellular traps (NETs) are known to exacerbate neurological deficits and worsen outcomes after stroke. This study explores the potential role of NETs in the pathogenesis of brain edema following ICH. The findings elucidated the effects of NETs on PHE, which offered promising insights for targeting NETs to relieve brain edema and secondary brain injury post-ICH.

血肿周围水肿 (PHE) 可显著加重脑出血 (ICH) 患者的继发性脑损伤，但其具体机制仍不清楚。已知中性粒细胞细胞外诱捕网 (NETs) 会加剧神经功能缺损并使卒中后的结果恶化。这项研究探讨了NETs在ICH后脑水肿发病机理中的潜在作用。研究结果阐明了NETs对PHE的影响，为靶向NETs减轻脑出血后脑水肿和继发性脑损伤提供了有希望的见解。

REF: Tang J, Yue J, Tao Y, et al. Neutrophil Extracellular Traps Induce Brain Edema Around Intracerebral Hematoma via ERK-Mediated Regulation of MMP9 and AQP4. Transl Stroke Res. Published online December 28, 2024. doi:10.1007/s12975-024-01318-w PMID: 39733198

The Impact of Postprocedural Anticoagulant Use in Patients Undergoing Woven EndoBridge: A Multicenter Propensity Score-Matched Study

WEB患者术后使用抗凝剂的影响: 一项多中心倾向评分匹配研究

The Woven EndoBridge (WEB) device has become a prominent treatment for wide-neck bifurcation intracranial aneurysms since its FDA approval in 2018. However, the impact of anticoagulant therapy on its efficacy and patient outcomes remains underexplored. This study aims to evaluate the effects of postoperative anticoagulant use on aneurysm occlusion, retreatment rates, and functional outcomes following WEB device implantation. The findings suggest that the WEB mechanism of occlusion is more complex than what have been hypothesized and highlight the need for individualized management strategies to optimize outcomes in patients requiring anticoagulation post-WEB. Further studies are needed.

自2018年FDA批准以来，WEB (WEB) 设备已成为宽颈分叉颅内动脉瘤的重要治疗方法。然而，抗凝治疗对其疗效和患者预后的影响仍未得到充分研究。这项研究旨在评估术后使用抗凝剂对动脉瘤闭塞，再治疗率和网络设备植入后功能结局的影响。研究结果表明，闭塞的网络机制比假设的要复杂得多，并强调了个性化管理策略的必要性，以优化需要抗凝治疗的患者的预后。需要进一步研究。

REF: Musmar B, Salim HA, Roy JM, et al. The Impact of Postprocedural Anticoagulant Use in Patients Undergoing Woven EndoBridge: A Multicenter Propensity Score-Matched Study. Transl Stroke Res. Published online December 24, 2024. doi:10.1007/s12975-024-01320-2 PMID: 39715904

Global and Regional Burden of Ischemic Stroke Disease from 1990 to 2021: An Age-Period-Cohort Analysis

1990年至2021年全球和地区缺血性卒中疾病负担: 年龄阶段队列分析

Ischemic stroke is a significant global public health issue that impacts health burdens across various regions. This study analyzed data from the Global Burden of Disease Study 2021 to assess the incidence, mortality, and disability-adjusted life years (DALYs) associated with ischemic stroke worldwide and across different Socio-demographic Index (SDI) regions. This highlights the urgent need for preventive and therapeutic strategies targeting ischemic stroke, particularly for individuals over 45, while addressing the impact of major risk factors in high-burden regions.

缺血性卒中是一个重要的全球公共卫生问题，影响着各个地区的健康负担。这项研究分析了全球疾病负担研究2021的数据，以评估全球和不同社会人口统计学指数 (SDI) 地区与缺血性卒中相关的发病率，死亡率和残疾调整生命年 (DALYs)。这凸显了迫切需要针对缺血性卒中的预防和治疗策略，特别是对于45岁以上的个体，同时解决高负担地区主要风险因素的影响。

REF: Zhu W, He X, Huang D, et al. Global and Regional Burden of Ischemic Stroke Disease from 1990 to 2021: An Age-Period-Cohort Analysis [published correction appears in Transl Stroke Res. 2025 Jan 9. doi: 10.1007/s12975-025-01325-5]. Transl Stroke Res. Published online December 19, 2024. doi:10.1007/s12975-024-01319-9 PMID: 39699770

Proteomic Composition of Acute Ischemic Stroke Thrombi Retrieved via Endovascular Thrombectomy Is Associated with Stroke Etiology

通过血管内血栓切除术获得的急性缺血性卒中血栓的蛋白质组学组成与卒中病因相关

The objective of this study is to investigate the protein components of acute ischemic stroke (AIS) thrombi using four-dimensional independent data acquisition (4D-DIA) proteomics and reveal the correlations between thrombotic protein components and AIS etiology. This study outlines a promising molecular approach to differentiating the etiology of AIS between CE and LAA through the proteomics of retrieved thrombi, which might also inform future research into thrombotic biology.

这项研究的目的是使用四维独立数据采集 (4D-DIA) 蛋白质组学研究急性缺血性卒中 (AIS) 血栓的蛋白质成分，并揭示血栓形成蛋白成分与AIS病因之间的相关性。这项研究概述了一种有前途的分子方法，通过检索到的血栓的蛋白质组学来区分CE和LAA之间的AIS病因，这也可能为未来的血栓生物学研究提供信息。

REF: Jiang RH, Liu XL, Xu XQ, Shi HB, Liu S. Proteomic Composition of Acute Ischemic Stroke Thrombi Retrieved via Endovascular Thrombectomy Is Associated with Stroke Etiology. Transl Stroke Res. Published online December 18, 2024. doi:10.1007/s12975-024-01317-x PMID: 39693038

Enlarged Perivascular Spaces (EPVS) Associated with Functional and Cognitive Outcome After Aneurysm Subarachnoid Hemorrhage (aSAH)

动脉瘤蛛网膜下腔出血 (aSAH) 后与功能和认知结果相关的扩大的血管周围空间 (EPVS)

Aneurysmal rupture is the main cause of subarachnoid hemorrhage (SAH), leading to neurological and cognitive deficits. The clinical significance of enlarged perivascular spaces (EPVS) on aSAH (aneurysm subarachnoid hemorrhage) outcomes was unclear. Our aim was to explore the association between EPVS and the clinical outcomes of aSAH. Our cohort study reveals that both BG-EPVS and CSO-EPVS are independently associated with unfavorable functional outcomes after aSAH. However, only CSO-EPVS, not BG-EPVS, is related to cognitive impairment at 3 months.

动脉瘤破裂是蛛网膜下腔出血 (SAH) 的主要原因，导致神经和认知功能障碍。血管周围间隙扩大 (EPVS) 对动脉瘤蛛网膜下腔出血 (aSAH) 结局的临床意义尚不清楚。我们的目的是探讨EPVS与aSAH临床结果之间的关系。我们的队列研究表明，bg-epvs和CSO-EPVS与aSAH后不良功能结局独立相关。然而，只有cso-epvs，而不是bg-epvs，与3个月时的认知障碍有关。

REF: Wang H, Yu Q, Zhang W, et al. Enlarged Perivascular Spaces (EPVS) Associated with Functional and Cognitive Outcome After Aneurysm Subarachnoid Hemorrhage (aSAH). Transl Stroke Res. Published online December 16, 2024. doi:10.1007/s12975-024-01315-z PMID: 39680240

Evaluating the Monro-Kellie Doctrine: Contralateral Hemisphere Shrinkage in Intracerebral Hemorrhage Patients

评估monro-kellie学说: 脑出血患者的对侧半球收缩

Intracerebral hemorrhage (ICH) along with aggravating factors, such as edema, can raise intracranial pressure (ICP) to pathological levels. Diversion of some cerebrospinal fluid (CSF) and venous blood out of the cranium can limit ICP rises while maintaining cerebral perfusion pressure. Brain tissue itself is widely considered immutable in volume but prone to distortion (e.g., midline shift). However, distal brain regions shrink acutely following ICH in rodents. Tissue contraction arises from cell shrinkage and increased packing density. This "tissue compliance" is hypothesized to be an additional mechanism to limit ICP rises. Here, we examined whether and by how much parenchyma volume reduction occurs in ICH patients. The findings suggest that distal parenchymal shrinkage may be a major compliance mechanism after ICH; the implications for ICP and brain function merit further study.

脑出血 (ICH) 伴随水肿等加重因素，可使颅内压 (ICP) 升高至病理水平。从颅骨中转移一些脑脊液 (CSF) 和静脉血可以限制ICP升高，同时保持脑灌注压。脑组织本身被广泛认为是体积不可变的，但容易变形 (例如，中线移位)。然而，啮齿动物ICH后远端大脑区域会急剧缩小。组织收缩是由细胞收缩和堆积密度增加引起的。假设这种 “组织顺应性” 是限制ICP升高的附加机制。在这里，我们检查了ICH患者是否以及实质体积减少了多少。研究结果表明，远端实质收缩可能是ICH后的主要顺应性机制; 对ICP和脑功能的影响值得进一步研究。

REF: Khiabani E, Kalisvaart ACJ, Wilkinson CM, Hurd PL, Buck BH, Colbourne F. Evaluating the Monro-Kellie Doctrine: Contralateral Hemisphere Shrinkage in Intracerebral Hemorrhage Patients. Transl Stroke Res. Published online December 11, 2024. doi:10.1007/s12975-024-01316-y PMID: 39658734

TdCCA with Dual-Modal Signal Fusion: Degenerated Occipital and Frontal Connectivity of Adult Moyamoya Disease for Early Identification

具有双模态信号融合的TdCCA: 成人烟雾病的退化枕叶和额叶连接的早期识别

Cognitive impairment in patients with moyamoya disease (MMD) manifests earlier than clinical symptoms. Early identification of brain connectivity changes is essential for uncovering the pathogenesis of cognitive impairment in MMD. We proposed a temporally driven canonical correlation analysis (TdCCA) method to achieve dual-modal synchronous information fusion from electroencephalogram (EEG) and functional near-infrared spectroscopy (fNIRS) for exploring the differences in brain connectivity between MMD and normal control groups. This study contributes to the understanding of the neurophysiological nature of cognitive impairment in MMD and provides a potential adjuvant early identification method for individuals with chronic cerebral ischemia.

烟雾病 (MMD) 患者的认知障碍比临床症状更早出现。早期识别脑连接变化对于揭示MMD认知障碍的发病机制至关重要。我们提出了一种时间驱动的典型相关分析 (TdCCA) 方法，以实现来自脑电图 (EEG) 和功能性近红外光谱 (fNIRS) 的双模态同步信息融合，以探索MMD与正常对照组之间大脑连通性的差异。这项研究有助于理解MMD认知障碍的神经生理学性质，并为慢性脑缺血个体提供潜在的辅助早期识别方法。

REF: Ran Y, Fan Y, Wu S, et al. TdCCA with Dual-Modal Signal Fusion: Degenerated Occipital and Frontal Connectivity of Adult Moyamoya Disease for Early Identification. Transl Stroke Res. Published online December 5, 2024. doi:10.1007/s12975-024-01313-1 PMID: 39636478

Comparative Analysis of Stent-Assisted Versus Non-Stent-Assisted Coiling in the Management of Ruptured Intracranial Aneurysms: A Systematic Review and Meta-Analysis

支架辅助与非支架辅助弹簧圈栓塞治疗颅内动脉瘤破裂的系统综述和Meta分析

This is to systematically evaluate the safety and efficacy of SAC compared to non-SAC in the treatment of RIA, integrating evidence from high-quality studies to guide clinical practice. SAC significantly improves long-term occlusion rates for RIA compared to non-SAC, despite a higher incidence of complications. Careful patient selection and optimization of antiplatelet therapy may enhance the safety and efficacy of SAC for RIA treatment.

这是为了系统地评估SAC与非SAC相比在RIA治疗中的安全性和有效性，整合高质量研究的证据以指导临床实践。与非SAC相比，SAC显着改善了RIA的长期闭塞率，尽管并发症的发生率更高。谨慎的患者选择和抗血小板治疗的优化可能会增强SAC用于RIA治疗的安全性和有效性。

REF: Ma YH, He YL, Zhang XY, et al. Comparative Analysis of Stent-Assisted Versus Non-Stent-Assisted Coiling in the Management of Ruptured Intracranial Aneurysms: A Systematic Review and Meta-Analysis. Transl Stroke Res. Published online December 4, 2024. doi:10.1007/s12975-024-01314-0 PMID: 39630412