Altered cortical thickness and structural covariance networks in upper limb amputees: A graph theoretical analysis

上肢截肢者皮质厚度改变与结构协方差网络的图论分析

Schematic diagram of steps involved (left-to-right) in producing and evaluating structural covariance networks (SCNs) based on the cortical thickness (CTh) of ULA and HC participants. Green-to-blue areas in semi-inflated brain surfaces (left box) represent differing CThs. The HCP 360 Atlas was used to parcellate ROIs for subsequent construction of SCNs using Pearson's correlations between each pair of corrected ROIs in ULA and HC groups. Structural correlation matrices (third from left) were calculated separately for each group to finally obtain binarized, unweighted, and undirected graph (right) used for graph theoretical analysis. Colors in structural correlation matrices represent weakest-to-strongest correlation (blue-to-red). HCP 360, Human Connectome Project Atlas; HCs, healthy controls; ROI, region of interest; ULAs, upper limb amputees.

根据ULA和HC参与者的皮质厚度(Cth)生成和评估结构协方差网络(SCN)的步骤示意图(从左到右)。半充气脑表面的绿色到蓝色区域(左框)代表不同的CTH。使用HCP360图谱来分割感兴趣区，以用于随后构建SCN，使用皮尔逊相关性在ULA和HC组中的每对校正ROI之间建立相关性。分别计算每组的结构相关矩阵(左三)，最终得到用于图论分析的二值化、未加权和无向图(右)。结构相关矩阵中的颜色表示从弱到强的相关性(从蓝到红)。HCP 360，人类连接组计划图谱；HCS，健康对照；ROI，感兴趣区；ULAS，上肢截肢者。

REF: Bao B, Sun Y, Lin J, et al. Altered cortical thickness and structural covariance networks in upper limb amputees: A graph theoretical analysis [published online ahead of print, 2023 Apr 30]. CNS Neurosci Ther. 2023;10.1111/cns.14226. doi:10.1111/cns.14226 PMID: 37122148

Therapeutic potential of aromatic plant extracts in Alzheimer's disease: Comprehensive review of their underlying mechanisms

芳香植物提取物治疗阿尔茨海默病的潜力：其潜在机制的综合综述

The aim of this review is to outline recent advancements in the application and mechanistic studies of aromatic plant extracts in Alzhermer`s disease (AD) to demonstrate their value in the management of this disease. This review provides a future strategy for the research of novel anti-AD drugs from aromatic plant extracts.

本综述旨在概述芳香植物提取物在阿尔茨海默病(AD)中的应用及其作用机制研究的最新进展，以证明其在阿尔茨海默病(AD)治疗中的价值。该综述为芳香植物提取物抗AD新药的研究提供了新的策略。

REF: Ma Y, Li Y, Yin R, et al. Therapeutic potential of aromatic plant extracts in Alzheimer's disease: Comprehensive review of their underlying mechanisms [published online ahead of print, 2023 Apr 30]. CNS Neurosci Ther. 2023;10.1111/cns.14234. doi:10.1111/cns.14234 PMID: 37122144

Machine learning for prediction of delirium in patients with extensive burns after surgery

机器学习对大面积烧伤患者术后精神障碍的预测

Developed and validated the first delirium prediction model for patients with extensive burns. The predictive model can effectively identify high-risk patients for intervention, reduce the incidence of delirium, alleviate the physical, psychological, and financial burden on patients, and rationalize the allocation of healthcare resources.

开发并验证了第一个用于大面积烧伤患者的妄想预测模型。该预测模型可以有效地识别高危患者进行干预，降低精神障碍的发生率，减轻患者的身体、心理和经济负担，合理配置医疗资源。

REF: Ren Y, Zhang Y, Zhan J, et al. Machine learning for prediction of delirium in patients with extensive burns after surgery [published online ahead of print, 2023 Apr 30]. CNS Neurosci Ther. 2023;10.1111/cns.14237. doi:10.1111/cns.14237 PMID: 37122154

Eltoprazine modulated gamma oscillations on ameliorating L-dopa-induced dyskinesia in rats

依托品调节伽玛振荡改善L-多巴诱导的大鼠运动障碍

The cumulative effects of chronic L-dopa administration on gamma oscillations; The impactors affect gamma oscillations in distinct regions in LID state; The abnormal functional connectivity in LID state; The potential mechanism of eltoprazine's amelioration of dyskinesia at the electrophysiological level in rats.

L-多巴长期给药对大鼠伽玛振荡的累积作用；冲击波对LID状态下不同区域的伽马振荡的影响；LID状态下功能连接的异常；埃托吡嗪从电生理水平改善大鼠运动障碍的潜在机制。

REF: Bi Y, Wang P, Yu J, et al. Eltoprazine modulated gamma oscillations on ameliorating L-dopa-induced dyskinesia in rats [published online ahead of print, 2023 Apr 30]. CNS Neurosci Ther. 2023;10.1111/cns.14241. doi:10.1111/cns.14241 PMID: 37122156

Inhibiting leukocyte-endothelial cell interactions by Chinese medicine Tongxinluo capsule alleviates no-reflow after arterial recanalization in ischemic stroke

通心络胶囊抑制白细胞-内皮细胞相互作用减轻缺血性卒中动脉再通后无复流

Leukocyte-endothelial cell interactions mediated by multiple adhesion molecules and chemokines are an important cause of no-reflow after arterial recanalization in ischemic stroke. Chinese medicine Tongxinluo capsule could alleviate no-reflow via suppressing the interactions through modulating various leukocyte subtypes and inhibiting the expression of multiple inflammatory mediators.

多种黏附分子和趋化因子介导的白细胞-内皮细胞相互作用是缺血性卒中动脉再通后无复流的重要原因。中药通心络胶囊可能通过调节多种白细胞亚群，抑制多种炎症介质的表达，从而抑制相互作用，从而减轻无复流。

REF: Liu S, Zhang Z, He Y, et al. Inhibiting leukocyte-endothelial cell interactions by Chinese medicine Tongxinluo capsule alleviates no-reflow after arterial recanalization in ischemic stroke [published online ahead of print, 2023 Apr 30]. CNS Neurosci Ther. 2023;10.1111/cns.14242. doi:10.1111/cns.14242 PMID: 37122157

Circular RNA as biomarkers for acute ischemic stroke: A systematic review and meta-analysis

环状RNA作为急性缺血性卒中生物标志物的系统评价和荟萃分析

This review updated the latest knowledge about the role of circular RNAs in the development of acute ischemic stroke, and discussed the practicability of using them as the biomarker for diagnosis. This study will pave the way for future studies of competing endogenous RNAs in ischemic stroke and furthermore, comprehension of the molecular mechanisms behind stroke.

本文就环状RNA在急性缺血性卒中发生发展中的作用及其作为诊断生物标志物的可行性进行综述。这项研究将为未来研究缺血性卒中的内源性竞争RNA以及进一步理解卒中背后的分子机制铺平道路。

REF: Zhang X, Wan M, Min X, et al. Circular RNA as biomarkers for acute ischemic stroke: A systematic review and meta-analysis [published online ahead of print, 2023 Apr 26]. CNS Neurosci Ther. 2023;10.1111/cns.14220. doi:10.1111/cns.14220 PMID: 37186176

The neurotrophic activities of brain-derived neurotrophic factor are potentiated by binding with apigenin, a common flavone in vegetables, in stimulating the receptor signaling

脑源性神经营养因子的神经营养活性通过与芹菜素结合而增强，芹菜素是蔬菜中常见的一种黄酮类物质，可刺激受体信号传导。

In cultured human neuroblastoma SH-SY5Y cells and rat neurons, the synergistic effects of apigenin with BDNF in stimulating the BDNF-induced neurite outgrowth and protective effect against amyloid-beta was demonstrated: this synergism was mediated by a direct interaction between BDNF and apigenin, through activating the signaling cascade of high-affinity BDNF receptor, Trk B.

在培养的人神经母细胞瘤SH-SY5Y细胞和大鼠神经元上，证实了芹菜素和BDNF在刺激BDNF诱导的轴突生长和对抗淀粉样β蛋白的保护作用中的协同作用：这种协同作用是通过BDNF和芹菜素之间的直接相互作用，通过激活高亲和力的BDNF受体Trk B的信号级联而实现的。

REF: Gao AX, Xia TC, Lin LS, Dong TT, Tsim KW. The neurotrophic activities of brain-derived neurotrophic factor are potentiated by binding with apigenin, a common flavone in vegetables, in stimulating the receptor signaling [published online ahead of print, 2023 Apr 26]. CNS Neurosci Ther. 2023;10.1111/cns.14230. doi:10.1111/cns.14230 PMID: 37101380

Amphiregulin blockade decreases the levodopa-induced dyskinesia in a 6-hydroxydopamine Parkinson's disease mouse model

两性调节素阻断可减少6-羟基多巴胺帕金森病小鼠模型中左旋多巴诱发的运动障碍

Levodopa (L-DOPA) is considered the most reliable drug for treating Parkinson's disease (PD) clinical symptoms. Regrettably, long-term L-DOPA therapy results in the emergence of drug-induced abnormal involuntary movements (AIMs) in most PD patients. The mechanisms underlying motor fluctuations and dyskinesia induced by L-DOPA (LID) are still perplexing. Taken together, our results indicate unequivocal involvement of Areg in levodopa-induced dyskinesia, thus a target for therapy development.

左旋多巴(L-多巴)被认为是治疗帕金森病(PD)临床症状最可靠的药物。遗憾的是，长期服用L多巴可导致大多数帕金森病患者出现药物引起的异常不自主运动(AIMS)。L多巴(LID)引起的运动波动和运动障碍的机制仍然令人困惑。综上所述，我们的结果表明，ARG明确地参与了左旋多巴诱导的运动障碍，从而成为治疗发展的目标。

REF: Kambey PA, Liu WY, Wu J, et al. Amphiregulin blockade decreases the levodopa-induced dyskinesia in a 6-hydroxydopamine Parkinson's disease mouse model [published online ahead of print, 2023 Apr 26]. CNS Neurosci Ther. 2023;10.1111/cns.14229. doi:10.1111/cns.14229 PMID: 37101388

Trends in NLRP3 inflammasome research in ischemic stroke from 2011 to 2022: A bibliometric analysis

2011~2022年缺血性卒中NLRP3炎症组研究动态：文献计量学分析

In this work, we HistCite Pro 2.1, VOSviewer, CiteSpace software, and biblioshiny to analyzed 601 publications on NLRP3 in ischemic stroke using a bibliometric approach and systematically evaluated the status of recent NLRP3 research in ischemic stroke injury.

在这项工作中，我们用文献计量学的方法分析了601篇关于NLRP3在缺血性卒中中的文献，并系统地评价了NLRP3在缺血性卒中损伤中的研究现状。

REF: Zhu H, Zhang Y, Feng S, et al. Trends in NLRP3 inflammasome research in ischemic stroke from 2011 to 2022: A bibliometric analysis [published online ahead of print, 2023 Apr 23]. CNS Neurosci Ther. 2023;10.1111/cns.14232. doi:10.1111/cns.14232 PMID: 37088947