Metabolic syndrome severity and stroke risk: a longitudinal analysis in middle-aged and older chinese adults

代谢综合征严重程度与中风风险：一项针对中国中老年人的纵向分析

Metabolic syndrome (MetS) contributes to cerebrovascular disease in older adults. Traditional binary diagnostic criteria may not fully capture metabolic dysfunction or its impact on stroke risk. This study explores the relationship between MetS severity and stroke risk. Greater MetS severity is independently associated with increased stroke risk among middle-aged and older Chinese adults. These findings highlight the need for continuous surveillance of MetS severity and timely intervention to mitigate stroke burden in aging populations.

代谢综合征（MetS）会增加老年人患脑血管疾病的风险。传统的二元诊断标准可能无法全面反映代谢功能障碍及其对中风风险的影响。本研究探讨了代谢综合征严重程度与中风风险之间的关系。在中国中老年人中，代谢综合征严重程度越高，中风风险增加的可能性就越大，且这种关联是独立存在的。这些研究结果强调了持续监测代谢综合征严重程度并及时进行干预以减轻老年人群中风负担的必要性。

REF: Rong W, Zhu Z, Wang D, Shang W. Metabolic syndrome severity and stroke risk: a longitudinal analysis in middle-aged and older chinese adults. J Stroke Cerebrovasc Dis. 2026;35(3):108553. doi:10.1016/j.jstrokecerebrovasdis.2026.108553 PMID: 41520739

Impact of prehospital comprehensive stroke center vs. primary stroke center triage protocol on outcome of patients with spontaneous intracerebral hemorrhage

院前综合卒中中心与初级卒中中心分诊方案对自发性脑出血患者预后的影响

While prehospital triage protocols for suspected large vessel occlusion (LVO) improve ischemic stroke outcomes, their impact in spontaneous intracerebral hemorrhage (sICH) remain uncertain. We evaluated whether a regional LVO-focused emergency medical service (EMS) transport protocol affected time-based process outcomes and clinical outcomes in sICH patients. Implementation of an LVO-focused EMS transport protocol did not improve clinical outcomes or time-based process outcomes among sICH patients, nor did it influence CSC admission or transfer rates. These findings suggest that while beneficial for ischemic stroke care, LVO triage protocols may not confer the same advantages for sICH patients and may require tailored approaches for this population.

虽然针对疑似大血管闭塞（LVO）的院前分诊方案可改善缺血性卒中的预后，但这些方案对自发性脑出血（sICH）的影响仍不确定。我们评估了以区域LVO为重点的紧急医疗服务（EMS）转运方案是否会影响sICH患者基于时间的流程结局和临床结局。实施以LVO为重点的EMS转运方案并未改善sICH患者的临床结局或基于时间的流程结局，也未影响综合卒中中心（CSC）的收治率或转诊率。这些研究结果表明，尽管LVO分诊方案对缺血性卒中的治疗有益，但可能无法为sICH患者带来同样的益处，可能需要针对这一人群制定特定的方案。

REF: Fan TH, Lawrence M, Goicoechea EB, Wick A, Prabhakaran S. Impact of prehospital comprehensive stroke center vs. primary stroke center triage protocol on outcome of patients with spontaneous intracerebral hemorrhage. J Stroke Cerebrovasc Dis. 2026;35(3):108555. doi:10.1016/j.jstrokecerebrovasdis.2026.108555 PMID: 41513161

Outcomes of low-dose versus standard-dose alteplase in acute ischemic stroke patients aged over 80 years: A real-world propensity score-matched study from China

80岁以上急性缺血性脑卒中患者低剂量与标准剂量阿替普酶治疗结局：一项来自中国的真实世界倾向评分匹配研究

Optimal alteplase dosing for intravenous thrombolysis in stroke patients aged >80 years remains debated due to underrepresentation in pivotal trials. This study evaluates the relative effectiveness and safety of low-dose (0.6 mg/kg) versus standard-dose (0.9 mg/kg) alteplase in elderly patients treated within 4.5 hours of onset. In octogenarian stroke patients, low-dose alteplase offers parallel efficacy and safety to standard therapy, with a possible reduction in hemorrhagic complications. These results support low-dose regimens as a reasonable option for elderly patients, particularly when minimizing bleeding risk is a clinical priority.

由于关键试验中80岁以上人群代表性不足，对于80岁以上卒中患者静脉溶栓时阿替普酶的最佳剂量仍存在争议。本研究评估了发病4.5小时内接受治疗的老年患者使用低剂量（0.6 mg/kg）与标准剂量（0.9 mg/kg）阿替普酶的相对有效性和安全性。对于80岁以上的卒中患者，低剂量阿替普酶与标准治疗的疗效和安全性相当，且可能减少出血并发症。这些结果表明，低剂量方案是老年患者的合理选择，尤其是当降低出血风险是临床首要考虑因素时。

REF: Li CS, Gu HQ, Yang KX, et al. Outcomes of low-dose versus standard-dose alteplase in acute ischemic stroke patients aged over 80 years: A real-world propensity score-matched study from China. J Stroke Cerebrovasc Dis. 2026;35(3):108548. doi:10.1016/j.jstrokecerebrovasdis.2026.108548 PMID: 41494566

Assessment of perioperative outcome factors after hemicraniectomy confirms age as the prognostic factor in patients with middle cerebral artery infarction: Evidence from real-world data

大脑半球切除术围手术期结局因素评估证实年龄是大脑中动脉梗死患者的预后因素：来自真实世界数据的证据

Malignant middle cerebral artery (MCA) infarction is a serious condition for which hemicraniectomy can improve survival and outcome. However, it remains unclear to what extent other perioperative factors contribute to the outcome. Our data provide information about changes in the degree of impairment and its improvement over time beyond the acute phase of stroke. Of all included parameters, age emerged as the most important prognostic factor.

恶性大脑中动脉（MCA）梗死是一种严重的病症，去骨瓣减压术可改善患者的生存率和预后。然而，其他围手术期因素对预后的影响程度仍不清楚。我们的数据提供了有关卒中急性期过后损伤程度变化及其随时间改善情况的信息。在所有纳入的参数中，年龄是最重要的预后因素。

REF: Isemann R, Wild F, Bronzlik P, Krauss JK, Stüber T, Sühs KW. Assessment of perioperative outcome factors after hemicraniectomy confirms age as the prognostic factor in patients with middle cerebral artery infarction: Evidence from real-world data. J Stroke Cerebrovasc Dis. 2026;35(3):108557. doi:10.1016/j.jstrokecerebrovasdis.2026.108557 PMID: 41534766

Temporal trends in heart failure and stroke-related mortality in the United States, 1999–2023

1999 - 2023年美国心力衰竭和中风相关死亡率的时间趋势

Heart failure (HF) and stroke remain among the leading causes of cardiovascular mortality in the U.S. However, the intersection of these two conditions has been underexplored in national mortality data. This study investigates temporal, demographic, and geographic trends in stroke-related deaths among individuals with HF from 1999 to 2023. Despite long-term mortality declines, recent reversals-especially post-pandemic and among younger, male, and racially minoritized populations-signal urgent gaps in equity and access.

在美国，心力衰竭（HF）和中风仍是心血管疾病死亡的主要原因。然而，在全国死亡数据中，这两种疾病的交集情况尚未得到充分研究。本研究调查了1999年至2023年期间心力衰竭患者中风相关死亡的时间、人口统计学和地理趋势。尽管长期来看死亡率有所下降，但近期出现了逆转情况，尤其是在疫情之后，以及在较年轻、男性和少数族裔人群中，这表明在公平性和可及性方面存在亟待解决的问题。

REF: Bilal AR, Sajid M, Qureshi S, et al. Temporal trends in heart failure and stroke-related mortality in the United States, 1999-2023. J Stroke Cerebrovasc Dis. 2026;35(3):108538. doi:10.1016/j.jstrokecerebrovasdis.2025.108538 PMID: 41475590

Quality of life after decompressive surgery for severe cerebral venous thrombosis

重度脑静脉血栓形成减压手术后的生活质量

Decompressive surgery can be lifesaving in patients with severe cerebral venous thrombosis (CVT) and impending brain herniation. However, data on health-related quality of life (HRQoL) after surgery are limited. Twelve months after decompressive surgery for CVT, over 4 out of 5 survivors reported problems in at least one subdomain of the EQ5D-3 L. Higher age, middle-income country status and preoperative coma were negative predictors of quality of life.

减压手术对患有严重脑静脉血栓形成（CVT）且即将发生脑疝的患者具有挽救生命的作用。然而，关于术后健康相关生活质量（HRQoL）的数据有限。CVT减压手术12个月后，超过五分之四的幸存者报告在EQ5D - 3L的至少一个子领域存在问题。年龄较大、中等收入国家身份以及术前昏迷是生活质量的负面预测因素。

REF: Sanchez van Kammen M, Aaron S, Ferreira JM, et al. Quality of life after decompressive surgery for severe cerebral venous thrombosis. J Stroke Cerebrovasc Dis. 2026;35(3):108549. doi:10.1016/j.jstrokecerebrovasdis.2026.108549 PMID: 41500360

Management of intracranial aneurysms: a 2024 nationwide study from China

颅内动脉瘤的管理：2024年中国全国性研究

Rising detection of unruptured intracranial aneurysms (UIAs) in China, driven by an aging population and increased neuroimaging utilization, coincides with significant regional disparities in neurointerventional resources. This study characterizes contemporary management practices nationwide. Significant practice variations persist in China, driven by experience gaps and regional resource inequities. Standardized training and equitable resource allocation are urgently needed to optimize aneurysm care.

在中国，由于人口老龄化和神经影像学检查应用的增加，未破裂颅内动脉瘤（UIAs）的检出率不断上升，与此同时，神经介入资源存在显著的区域差异。本研究描述了全国范围内当前的治疗实践情况。中国仍然存在显著的治疗实践差异，这是由经验差距和区域资源分配不均所导致的。为了优化动脉瘤的治疗，迫切需要开展标准化培训并进行公平的资源分配。

REF: Gao Y, Huyan M, Wu Y, et al. Management of intracranial aneurysms: a 2024 nationwide study from China. J Stroke Cerebrovasc Dis. 2026;35(3):108546. doi:10.1016/j.jstrokecerebrovasdis.2026.108546 PMID: 41485587

Transcatheter closure versus antithrombotic therapy for cryptogenic stroke in elderly patients with patent foramen ovale: a systematic review and meta-analysis of non-randomized studies

经导管封堵术与抗栓治疗对合并卵圆孔未闭的老年隐源性卒中患者的疗效比较：一项非随机研究的系统评价和Meta分析

There is lacking of robust clinical evidence comparing transcatheter closure with antithrombotic therapy in elderly patent foramen ovale (PFO) patients with cryptogenic stroke. PFO closure might reduce the risk of composite endpoint of recurrent stroke and TIA and all-cause death, while not increase the risk of new-onset atrial fibrillation comparing with medication therapy in elderly PFO patients with cryptogenic stroke. PFO closure should be considered part of a comprehensive secondary prevention strategy in elderly patients.

在隐源性卒中的老年卵圆孔未闭（PFO）患者中，缺乏比较经导管封堵与抗栓治疗的有力临床证据。与药物治疗相比，在隐源性卒中的老年PFO患者中，PFO封堵可能降低复发性卒中和短暂性脑缺血发作（TIA）复合终点以及全因死亡的风险，同时不增加新发心房颤动的风险。在老年患者中，PFO封堵应被视为综合二级预防策略的一部分。

REF: Dong Y, Lu C, Luo T, Huang H, Xiong Y, Zeng J. Transcatheter closure versus antithrombotic therapy for cryptogenic stroke in elderly patients with patent foramen ovale: a systematic review and meta-analysis of non-randomized studies. J Stroke Cerebrovasc Dis. 2026;35(3):108562. doi:10.1016/j.jstrokecerebrovasdis.2026.108562 PMID: 41547485

Aspirin-ticagrelor use after mild acute ischemic stroke: Findings from the get with the guidelines-stroke registry

轻度急性缺血性卒中后阿司匹林-替格瑞洛的应用：来自“遵循指南-卒中”注册研究的结果

Recent guidelines suggest that aspirin-ticagrelor may be considered for stroke prevention after mild acute ischemic stroke. However, it is unclear how commonly this dual antiplatelet therapy (DAPT) regimen is used in practice. Unlike aspirin-clopidogrel, aspirin-ticagrelor is infrequently administered after mild acute ischemic stroke (NIHSS <6) despite current guidelines, though the use of both DAPT regimens increased over time.

近期指南建议，对于轻度急性缺血性脑卒中患者，可考虑使用阿司匹林 - 替格瑞洛进行卒中预防。然而，目前尚不清楚这种双重抗血小板治疗（DAPT）方案在实际中使用的普遍程度。与阿司匹林 - 氯吡格雷不同，尽管有现行指南推荐，但在轻度急性缺血性脑卒中（美国国立卫生研究院卒中量表评分 <6）后，阿司匹林 - 替格瑞洛的使用并不常见，不过这两种 DAPT 方案的使用随着时间推移均有所增加。

REF: Liberman AL, Zhang C, Rostanski SK, et al. Aspirin-ticagrelor use after mild acute ischemic stroke: Findings from the get with the guidelines-stroke registry. J Stroke Cerebrovasc Dis. 2026;35(3):108564. doi:10.1016/j.jstrokecerebrovasdis.2026.108564 PMID: 41565167