Risk Factors for Increased Surgical Drain Output in Patients After Unilateral Expansive Open-Door Cervical Laminoplasty for Cervical Compressive Myelopathy: A Retrospective Study of 341 Patients

单开门扩大颈椎椎板成形术治疗颈椎压迫性脊髓病患者术后引流量增加的危险因素：一项341例患者的回顾性研究

This study aimed to investigate determinants independently correlated with increased surgical drain output (ISDO) observed following unilateral expansive open-door cervical laminoplasty (UEOCL) procedures performed in individuals diagnosed with cervical spondylotic myelopathy. Multivariate analysis identified male gender, younger age (below 60 years), elevated preoperative diastolic blood pressure, and lateral mass screw fixation as independent predictors of ISDO development post-UEOCL. Furthermore, the presence of ISDO demonstrated significant correlations with prolonged hospitalization duration and elevated inpatient financial expenditures.

本研究旨在探究与诊断为脊髓型颈椎病的患者行单侧扩大开门颈椎椎板成形术（UEOCL）后观察到的手术引流液量增加（ISDO）独立相关的影响因素。多变量分析确定，男性、年龄较轻（60岁以下）、术前舒张压升高以及侧块螺钉固定是UEOCL术后发生ISDO的独立预测因素。此外，ISDO的存在与住院时间延长和住院费用增加显著相关。

REF: Wang H, Zhai S, Zhang Z, et al. Risk Factors for Increased Surgical Drain Output in Patients After Unilateral Expansive Open-Door Cervical Laminoplasty for Cervical Compressive Myelopathy: A Retrospective Study of 341 Patients. World Neurosurg. 2025;201:124271. doi:10.1016/j.wneu.2025.124271 PMID: 40653014

Intraoperative Assessment of Right Cingulum Function Using the Williams Inhibition Test During Awake Surgery for Right Frontal Gliomas

右侧额叶胶质瘤清醒手术中使用威廉姆斯抑制试验对右侧扣带束功能进行术中评估

The cingulum is crucial for cognitive control and functionally relevant in various neurological diseases, including brain tumors. This study evaluated the usefulness of the Williams Inhibition Test (WIT), a Stroop-like task reflecting nonverbal cognitive control, in assessing cingulum function during awake surgery for right frontal gliomas. Intraoperative use of WIT may aid in identifying functional cingulum regions and is associated with better neurocognitive outcomes and comparable resection rates. These findings suggest that WIT may be a useful tool for monitoring cognitive control function during awake surgery for right frontal gliomas.

扣带回对于认知控制至关重要，并且在包括脑肿瘤在内的各种神经系统疾病中具有功能相关性。本研究评估了威廉姆斯抑制测试（WIT）在评估右额叶胶质瘤清醒手术期间扣带回功能方面的实用性，该测试是一种类似斯特鲁普任务的测试，反映了非言语认知控制能力。术中使用 WIT 可能有助于识别扣带回的功能区域，并且与更好的神经认知结局和相当的切除率相关。这些发现表明，WIT 可能是右额叶胶质瘤清醒手术期间监测认知控制功能的有用工具。

REF: Nakajima R, Kinoshita M, Hirono S, et al. Intraoperative Assessment of Right Cingulum Function Using the Williams Inhibition Test During Awake Surgery for Right Frontal Gliomas. World Neurosurg. 2025;201:124266. doi:10.1016/j.wneu.2025.124266 PMID: 40633761

Clinical Outcomes of Microsurgical Flow Reconstruction in Long-Segment Cervical Internal Carotid Artery Stenosis with Distal Grade 2 or 3 Kinking

长节段颈内动脉狭窄合并远端2级或3级迂曲的显微外科血流重建临床结局

To evaluate the clinical outcomes of perivascular sympathectomy-assisted arteriolysis combined with kinking correction in patients with long-segment cervical internal carotid artery (ICA) stenosis accompanied by Grade 2 or 3 distal kinking. Microsurgical flow reconstruction using arteriolysis and perivascular sympathectomy with kinking correction is a promising technique for selected patients with complex cervical ICA stenosis not amenable to endovascular treatment. It achieves significant symptomatic relief and improves hemodynamic parameters without major complications.

评估血管周围交感神经切除术辅助动脉松解联合迂曲矫正术治疗长节段颈内动脉（ICA）狭窄伴2级或3级远端迂曲患者的临床疗效。对于不适合血管内治疗的复杂颈内动脉狭窄的特定患者，采用动脉松解和血管周围交感神经切除术并矫正迂曲的显微外科血流重建术是一种有前景的技术。该技术可显著缓解症状，改善血流动力学参数，且无重大并发症。

REF: Pinar E, Baylarov B, Cekic E, Akbulut F, Cosar A, Ustun ME. Clinical Outcomes of Microsurgical Flow Reconstruction in Long-Segment Cervical Internal Carotid Artery Stenosis with Distal Grade 2 or 3 Kinking. World Neurosurg. 2025;201:124281. doi:10.1016/j.wneu.2025.124281 PMID: 40669597

Navigate Transcranial Magnetic Stimulation Is More Reliable Than Tractography for Placing Subdural Electrodes Used for Cortico-Cortical-Evoked-Potentials Recording

导航式经颅磁刺激在放置用于记录皮质 - 皮质诱发电位的硬膜下电极方面比弥散张量成像纤维束成像更可靠

The aim of the study is to verify whether preoperative navigated transcranial magnetic stimulation (nTMS) is a reliable tool for the positioning of subdural electrodes for cortico-cortical evoked potentials (CCEPs) recording in the presence of minicraniotomy. Compared to tractography, nTMS shows a higher reliability in the placement of subdural electrodes used for CCEP recordings.

本研究的目的是验证在进行微型颅骨切开术的情况下，术前导航经颅磁刺激（nTMS）是否是用于定位用于记录皮质 - 皮质诱发电位（CCEPs）的硬膜下电极的可靠工具。与纤维束成像相比，nTMS 在用于 CCEP 记录的硬膜下电极放置方面显示出更高的可靠性。

REF: Carrai R, Battista F, Bonaudo C, et al. Navigate Transcranial Magnetic Stimulation Is More Reliable Than Tractography for Placing Subdural Electrodes Used for Cortico-Cortical-Evoked-Potentials Recording. World Neurosurg. 2025;201:124201. doi:10.1016/j.wneu.2025.124201 PMID: 40571276

Treatment Outcome in Elderly Traumatic Brain Injury Patients at a Level 2 Trauma Care Facility in a Low-Middle-Income Country

中低收入国家一家二级创伤护理机构老年创伤性脑损伤患者的治疗结局

Slower recovery and worse clinical outcome seen in elderly patients with TBI have made it a matter of concern. Medical literature is replete with studies on the outcomes of elderly TBI patients managed at level 1 and level 2 trauma centers in developed countries. However, the healthcare services in low-middle-income countries are far from an ideal scenario, and hence, the outcome will naturally be different. The injury profile and outcome of elderly TBI patients in a low-middle-income nation are markedly different, and the resources should be tailored accordingly, with a greater attention to strengthening home care services and conditioning programs.

老年创伤性脑损伤（TBI）患者恢复较慢且临床结局较差，这已成为一个备受关注的问题。医学文献中有大量关于发达国家一级和二级创伤中心收治的老年TBI患者预后情况的研究。然而，中低收入国家的医疗服务远非理想状况，因此，其治疗结局自然会有所不同。中低收入国家老年TBI患者的损伤情况和预后明显不同，应相应地调整资源配置，更加注重加强家庭护理服务和康复训练项目。

REF: Jyoti Mahakul D, Sharma T, Bhandarkar D, Jagetia A, Singh D, Agarwal J. Treatment Outcome in Elderly Traumatic Brain Injury Patients at a Level 2 Trauma Care Facility in a Low-Middle-Income Country. World Neurosurg. 2025;201:124203. doi:10.1016/j.wneu.2025.124203 PMID: 40550263

Low Bone Mineral Density as a Risk Factor for Cervical Sagittal Imbalance Following Laminoplasty

低骨密度作为椎板成形术后颈椎矢状面失衡的危险因素

To investigate the influence of preoperative bone mineral density (BMD) on cervical sagittal balance changes following laminoplasty and identify potential risk factors for postoperative cervical sagittal imbalance (CSI). Preoperative BMD level is significantly associated with CSI after laminoplasty. Patients with low preoperative BMD (<308.6 HU) are more likely to develop postoperative CSI with poorer clinical outcomes. For patients with preoperative low BMD, laminoplasty should be considered cautiously, with enhanced postoperative management to prevent postoperative CSI.

探讨术前骨密度（BMD）对椎板成形术后颈椎矢状面平衡变化的影响，并确定术后颈椎矢状面失衡（CSI）的潜在危险因素。术前骨密度水平与椎板成形术后的 CSI 显著相关。术前骨密度较低（<308.6 HU）的患者术后更易发生 CSI，且临床结局较差。对于术前骨密度较低的患者，应谨慎考虑椎板成形术，并加强术后管理以预防术后 CSI。

REF: Zheng B, Yu P, Zhu Z, Ma K, Liang Y, Liu H. Low Bone Mineral Density as a Risk Factor for Cervical Sagittal Imbalance Following Laminoplasty. World Neurosurg. 2025;201:124232. doi:10.1016/j.wneu.2025.124232 PMID: 40602489

Blood Biomarker-Based Machine Learning Model for Predicting Cognitive Impairment in Stroke Patients

基于血液生物标志物的机器学习模型用于预测卒中患者的认知障碍

Cognitive impairment (CI) is common in stroke patients and is associated with a poor prognosis. Early and accurate identification of high-risk patients is crucial. This study aims to develop a predictive model for CI risk in stroke patients using machine learning (ML). ML-based prediction models demonstrate high accuracy in assessing the risk of CI in stroke patients, enabling early intervention to improve outcomes.

认知障碍（CI）在中风患者中很常见，且与预后不良相关。早期准确识别高危患者至关重要。本研究旨在利用机器学习（ML）开发中风患者CI风险预测模型。基于机器学习的预测模型在评估中风患者CI风险方面表现出较高的准确性，有助于早期干预以改善预后。

REF: Zhao Y, Zeng D, Yu H, et al. Blood Biomarker-Based Machine Learning Model for Predicting Cognitive Impairment in Stroke Patients. World Neurosurg. 2025;201:124276. doi:10.1016/j.wneu.2025.124276 PMID: 40651606

Multiomics Integration of Mendelian Randomization Identifies Circulating Metabolites Causally Linked to Intracranial Aneurysm

孟德尔随机化多组学整合鉴定与颅内动脉瘤存在因果关联的循环代谢物

This study aimed to identify blood metabolites with potential causal effects on intracranial aneurysm (IA) risk using Mendelian randomization (MR) and to elucidate underlying molecular mechanisms via transcriptomic integration and experimental validation. This study identifies metabolite-gene signatures associated with IA and reveals candidate biomarkers and therapeutic targets, providing novel insights into IA pathogenesis and avenues for metabolic intervention.

本研究旨在利用孟德尔随机化（MR）方法确定对颅内动脉瘤（IA）风险具有潜在因果效应的血液代谢物，并通过转录组整合和实验验证阐明潜在的分子机制。本研究确定了与IA相关的代谢物 - 基因特征，揭示了候选生物标志物和治疗靶点，为IA的发病机制提供了新的见解，并为代谢干预提供了途径。

REF: Liu T, Yu K, Wang C, Jiang Y, Peng J. Multiomics Integration of Mendelian Randomization Identifies Circulating Metabolites Causally Linked to Intracranial Aneurysm. World Neurosurg. 2025;201:124272. doi:10.1016/j.wneu.2025.124272 PMID: 40651607

Neurosurgical Resident Skill Development Using a Novel Simulator-Based Anterior Cervical Discectomy and Fusion Curriculum

使用基于新型模拟器的前路颈椎间盘切除融合术培训课程培养神经外科住院医师技能

Simulation-based training is increasingly integrated into surgical education as a method to enhance technical skills in a safe and reproducible environment. This dual-institution pilot study - conducted within the neurosurgery residency programs at Massachusetts General Hospital and Stanford University - evaluates the feasibility and impact of integrating a three-dimensional printed anterior cervical discectomy and fusion (ACDF) simulator (UpSurgeon S.r.l), alongside spaced repetition learning in a novel simulator training curriculum. Incorporating a three-dimensional-printed ACDF simulator alongside spaced repetition learning in a novel training curriculum suggests potential for improving procedural timing and anatomical knowledge in neurosurgical trainees.

基于模拟的培训正越来越多地融入外科教育，作为一种在安全且可重复的环境中提升技术技能的方法。这项双机构试点研究——在麻省总医院和斯坦福大学的神经外科住院医师培训项目中开展——评估了在一种新颖的模拟训练课程中，将三维打印的前路颈椎间盘切除融合术（ACDF）模拟器（UpSurgeon S.r.l）与间隔重复学习相结合的可行性和影响。在新颖的培训课程中结合使用三维打印的ACDF模拟器和间隔重复学习，显示出提高神经外科实习医生手术操作时间把控能力和解剖学知识水平的潜力。

REF: Robertson FC, Zygourakis CC, Wu JY, et al. Neurosurgical Resident Skill Development Using a Novel Simulator-Based Anterior Cervical Discectomy and Fusion Curriculum. World Neurosurg. 2025;201:124257. doi:10.1016/j.wneu.2025.124257 PMID: 40619056