Population attributable fractions of established, social-psychological, and reproductive risk factors for stroke among women: Evidence from UK Biobank

女性中风已确定的、社会心理和生殖风险因素的人群归因分数：来自英国生物银行的证据

Stroke is a leading cause of death and disability worldwide, with women facing unique risks due to a combination of well-established, under-recognized, and female-specific factors. This prospective cohort study aimed to quantify the population attributable fractions (PAFs) of stroke with distinct risk factor profiles and to explore disparities across age strata. While the conventional risk factors contributed to the greatest stroke burden, the potential benefit of addressing issues related to unfavorable social-psychological conditions and adverse reproductive profiles should not be neglected. Integrated and targeted prevention strategies are in urgent need to protect women's cardio-cerebrovascular health throughout the lifespan.

中风是全球范围内导致死亡和残疾的主要原因之一，由于一系列已明确、未被充分认识以及女性特有的因素，女性面临着独特的中风风险。这项前瞻性队列研究旨在量化具有不同风险因素特征的中风人群归因分数（PAF），并探究不同年龄层之间的差异。虽然传统风险因素导致的中风负担最大，但解决不良社会心理状况和不良生殖特征相关问题的潜在益处不应被忽视。迫切需要制定综合且有针对性的预防策略，以在女性一生中保护其心脑血管健康。

REF: Sun W, Hou L, Wu J, Shan S, Song P. Population attributable fractions of established, social-psychological, and reproductive risk factors for stroke among women: Evidence from UK Biobank. Int J Stroke. Published online August 2, 2025. doi:10.1177/17474930251365865 PMID: 40751569

Quantification of brain tissue injury and prediction of prognosis using serum GFAP and UCH-L1: A multicenter prospective cohort study

利用血清胶质纤维酸性蛋白（GFAP）和泛素羧基末端水解酶 - L1（UCH - L1）量化脑组织损伤并预测预后：一项多中心前瞻性队列研究

It remains unclear whether the serum levels of the brain injury biomarkers (glial fibrillary acidic protein [GFAP] and ubiquitin C-terminal hydrolase-L1 [UCH-L1]) can be used to quantitatively evaluate brain tissue injury and predict prognosis in patients with intravenous thrombolysis (IVT). This study investigates the association between serum GFAP and UCH-L1 levels with functional outcomes in patients receiving IVT. Serum GFAP and UCH-L1 levels can be used to quantitatively evaluate brain tissue injury and predict the prognosis of patients with IVT.

目前尚不清楚脑损伤生物标志物（胶质纤维酸性蛋白 [GFAP] 和泛素羧基末端水解酶 - L1 [UCH - L1]）的血清水平是否可用于定量评估静脉溶栓（IVT）患者的脑组织损伤并预测预后。本研究探讨接受 IVT 治疗患者的血清 GFAP 和 UCH - L1 水平与功能结局之间的关联。血清 GFAP 和 UCH - L1 水平可用于定量评估 IVT 患者的脑组织损伤并预测其预后。

REF: Guo ZN, Qu Y, Abuduxukuer R, et al. Quantification of brain tissue injury and prediction of prognosis using serum GFAP and UCH-L1: A multicenter prospective cohort study. Int J Stroke. Published online August 2, 2025. doi:10.1177/17474930251366103 PMID: 40751573

Blood pressure threshold and outcomes after successful endovascular thrombectomy

血管内取栓成功后的血压阈值与预后情况

Several randomized clinical trials have indicated that intensive blood pressure (BP) lowering is associated with worse outcomes, leaving the optimal BP targets following endovascular thrombectomy (EVT) uncertain. Prolonged hypoperfusion below 100 mmHg and extreme surges above 190 mmHg, rather than specific SBP parameters, were associated with poor functional outcomes. These findings highlight the need for a threshold-based BP management approach post-EVT to minimize prolonged hypotension and excessive surges.

多项随机临床试验表明，强化降压与更差的预后相关，使得血管内血栓切除术（EVT）后的最佳血压目标尚不明确。血压持续低于100 mmHg的低灌注状态以及血压急剧升高超过190 mmHg的情况，而非特定的收缩压参数，与不良功能预后相关。这些研究结果强调，在血管内血栓切除术后需要采用基于阈值的血压管理方法，以尽量减少长时间低血压和血压急剧升高的情况。

REF: Jung JW, Lee H, Heo J, et al. Blood pressure threshold and outcomes after successful endovascular thrombectomy. Int J Stroke. Published online August 1, 2025. doi:10.1177/17474930251366063 PMID: 40747963