Genetically predicted white matter microstructure mediates the relationship between risk factors and lacunar stroke

基因预测的白质微观结构介导了危险因素与腔隙性卒中之间的关系

Lacunar stroke is a complex, multifactorial disease with significant genetic underpinnings. However, the mechanisms through which genetic predispositions and risk factors contribute to its pathogenesis remain poorly understood. We investigated whether genetically predicted white matter (WM) microstructure mediates causal relationships between risk factors and lacunar stroke. Hypertension may contribute to lacunar stroke pathogenesis in part through WM microstructure alterations, particularly in the ALIC. MD and ISOVF in the ALIC may serve as structural brain reserves and early biomarkers of hypertension-induced pathophysiology associated with lacunar stroke.

腔隙性卒中是一种复杂的多因素疾病，具有显著的遗传基础。然而，遗传易感性和危险因素导致其发病的机制仍知之甚少。我们研究了基因预测的白质（WM）微观结构是否介导了危险因素与腔隙性卒中之间的因果关系。高血压可能部分通过白质微观结构改变导致腔隙性卒中发病，尤其是在胼胝体前部的前肢（ALIC）。ALIC中的平均扩散率（MD）和各向同性分数（ISOVF）可能作为结构性脑储备以及与腔隙性卒中相关的高血压诱导病理生理学的早期生物标志物。

REF: Zhang J, Wu M, Neville D, et al. Genetically predicted white matter microstructure mediates the relationship between risk factors and lacunar stroke. Stroke Vasc Neurol. Published online June 26, 2025. doi:10.1136/svn-2025-004208 PMID: 40571410

Associations of accelerated biological ageing with incident dementia, cognitive functions and brain structure: a prospective cohort study based on UK Biobank

加速生物衰老与新发痴呆、认知功能和脑结构的关联：一项基于英国生物银行的前瞻性队列研究

Several small-sample studies have suggested that biological processes of ageing are implicated with dementia and cognitive function. We aimed to prospectively investigate the associations of biological age with incident dementia, cognitive functions and brain structure based on the UK Biobank. A higher level of biological age may represent a potential risk factor for incident dementia and is associated with worse performance in multiple cognitive domains and brain structural measures.

多项小样本研究表明，衰老的生物学过程与痴呆症和认知功能有关。我们旨在基于英国生物样本库前瞻性地研究生物年龄与新发痴呆症、认知功能和大脑结构之间的关联。较高的生物年龄水平可能是新发痴呆症的一个潜在危险因素，并且与多个认知领域的较差表现以及大脑结构指标相关。

REF: Zheng X, Han W, Li Y, et al. Associations of accelerated biological ageing with incident dementia, cognitive functions and brain structure: a prospective cohort study based on UK Biobank. Stroke Vasc Neurol. Published online June 3, 2025. doi:10.1136/svn-2024-003690 PMID: 40461154

Efficacy and safety of Y-3 intracalvariosseous injection versus intravenous injection in the treatment of acute large hemispheric infarction (SOLUTION-2): rationale and design of a multicentre, prospective, randomised, open-label, blind endpoint (PROBE) trial

Y - 3 颅内注射与静脉注射治疗急性大脑半球大面积梗死的有效性和安全性（SOLUTION - 2）：一项多中心、前瞻性、随机、开放标签、盲法终点评估（PROBE）试验的原理与设计

The blood-brain barrier (BBB) largely restricts the efficacy of neuroprotectants, which is an important approach in treating large hemispheric infarction (LHI). In this study, we harnessed intracalvariosseous (ICO) injection to bypass the BBB and facilitate drug delivery. To compare the efficacy and safety of ICO injection versus intravenous injection in the treatment of acute LHI within 24 hours of disease onset. Results from the SOLUTION-2 trial will contribute to the understanding of the efficacy and safety of the Y-3 ICO injection in patients with LHI.

血脑屏障（BBB）在很大程度上限制了神经保护剂的疗效，而使用神经保护剂是治疗大脑半球大面积梗死（LHI）的重要方法。在本研究中，我们采用颅骨内（ICO）注射的方式绕过血脑屏障，促进药物递送。旨在比较发病24小时内的急性LHI患者接受ICO注射与静脉注射的疗效和安全性。SOLUTION - 2试验的结果将有助于了解Y - 3 ICO注射治疗LHI患者的疗效和安全性。

REF: Wang N, Zhang M, Yang M, et al. Efficacy and safety of Y-3 intracalvariosseous injection versus intravenous injection in the treatment of acute large hemispheric infarction (SOLUTION-2): rationale and design of a multicentre, prospective, randomised, open-label, blind endpoint (PROBE) trial. Stroke Vasc Neurol. Published online June 3, 2025. doi:10.1136/svn-2024-004011 PMID: 40461153