Joshua Johansen 教授

日本理化研究所

we aim to provide better treatments for psychiatric and neurological conditions. Anxiety and chronic pain disorders are characterized by exaggerated emotional memory formation and an inability to override emotional reactions when they are inappropriate. Dysfunction in the circuits which trigger and control emotional learning and memory may underlie the clinical pathology associated with chronic pain and anxiety disorders. By understanding the circuit mechanisms of these processes and how they are dysregulated in disease states our ultimate goal is to provide better treatments for these debilitating conditions.

1 Watanabe M, Uematsu A, Johansen JP. Enhanced synchronization between prelimbic and infralimbic cortices during fear extinction learning. Mol Brain 2021, 14: 175.

2 Yeh LF, Ozawa T, Johansen JP. Functional organization of the midbrain periaqueductal gray for regulating aversive memory formation. Mol Brain 2021, 14: 136.

3 Poe GR, Foote S, Eschenko O, Johansen JP, Bouret S, Aston-Jones G, et al. Locus coeruleus: A new look at the blue spot. Nat Rev Neurosci 2020, 21: 644–659.

4 Narikiyo K, Mizuguchi R, Ajima A, Shiozaki M, Hamanaka H, Johansen JP, et al. The claustrum coordinates cortical slow-wave activity. Nat Neurosci 2020, 23: 741–753.

5 Likhtik E, Johansen JP. Neuromodulation in circuits of aversive emotional learning. Nat Neurosci 2019, 22:1946.

6 Gungor NZ, Johansen JP. A chronic pain in the ACC. Neuron 2019, 102:903–905.

7 Johansen JP, Seymour B. Editorial overview: Pain and aversive motivation. Curr Opin Behav Sci 2019, 26: iii–v.

8 Luo R, Uematsu A, Weitemier A, Aquili L, Koivumaa J, McHugh TJ, et al. A dopaminergic switch for fear to safety transitions. Nat Commun 2018, 9: 2483

9 Ozawa T, Johansen JP. Learning rules for aversive associative memory formation. Curr Opin Neurobiol 2018, 49:148–157.

10 Yeh LF, Watanabe M, Sulkes-Cuevas J, Johansen JP. Dysregulation of aversive signaling pathways: A novel circuit endophenotype for pain and anxiety disorders. Curr Opin Neurobiol 2018, 48: 37–44.

You can find more on their webpage.

李伟广 研究员

复旦大学

1、选取情绪记忆、摄食记忆、运动记忆等包含不同内容的记忆模型作为攻关对象，从多维度解析记忆印迹的基本特征及其神经生物学基础，以重构与合成为目标刻画情绪情感、营养代谢、运动行为等正常生命活动及其障碍发展的生理本质；

2、开拓记忆原理在脑-体交互调节中的应用，以记忆的视角审视慢性神经精神疾病的症状演变和康复；

3、探索外周或中枢规律性刺激使大脑活性发生“记忆”样长程改变的新模式及其可塑性机理，解析脑内具有明确促康复作用的特征性细胞集群的活性演化过程及其分子驱动力，发展基于记忆原理的疾病干预新策略，推进临床转化应用

1 Li WG, Wu YJ, Gu X, Fan HR, Wang Q, Zhu JJ, et al. Input associativity underlies fear memory renewal. Natl Sci Rev 2021, 8: nwab004.

2 Yan YH, Zhang LL, Zhu TL, Deng SN, Ma BK, Lv H, et al. Reconsolidation of a post-ingestive nutrient memory requires mTOR in the central amygdala. Mol Psychiatry 2021, 26: 2820–2836.

3 Wang Q, Wang Q, Song XL, Jiang Q, Wu YJ, Li Y, et al. Fear extinction requires ASIC1a-dependent regulation of hippocampal-prefrontal correlates. Sci Adv 2018, 4: eaau3075.

4 Yu Z, Wu YJ, Wang YZ, Liu DS, Song XL, Jiang Q, et al. The acid-sensing ion channel ASIC1a mediates striatal synapse remodeling and procedural motor learning. Sci Signal 2018, 11: eaar4481.

5 Fan HR, Du WF, Zhu T, Wu YJ, Liu YM, Wang Q, et al. Quercetin reduces cortical GABAergic transmission and alleviates MK-801-induced hyperactivity. EBioMedicine 2018, 34: 201–213.

6 Li WG, Liu MG, Deng SN, Liu YM, Shang L, Ding J, et al. ASIC1a regulates insular long-term depression and is required for the extinction of conditioned taste aversion. Nat Commun 2016, 7: 13770.

7 Peng Z, Li WG, Huang C, Jiang YM, Wang X, Zhu MX, et al. ASIC3 mediates itch sensation in response to coincident stimulation by acid and nonproton ligand. Cell Rep 2015, 13: 387–398.

8 Yu Y, Chen Z, Li WG, Cao H, Feng EG, Yu F, et al. A nonproton ligand sensor in the acid-sensing ion channel. Neuron 2010, 68: 61–72.

You can find more on their webpage.

徐春 研究员

脑智卓越中心

1  Qu X, Wu J, Chen L, Lv S, Liu L, Zhan L, et al. A virtual reality platform for context-dependent cognitive research in rodents. Neurosci Bull (In Press).

2 Chen HS, Zhang XL, Yang RR, Wang GL, Zhu XY, Xu YF, et al. An intein-split transactivator for intersectional neural imaging and optogenetic manipulation. Nat Commun 2022, 13: 3605.

3 Gao L, Liu S, Gou LF, Hu YC, Liu YH, Deng L, et al. Single-neuron projectome of mouse prefrontal cortex. Nat Neurosci 2022, 25: 515–529.

4 Li YM, Zhan LJ, wang Y, Chen RR, Yang XW, Wu XT, et al. Improve the spatial resolution of fiber photometry by μLED linear array for fluorescence detection. Sens Actuat A Phys 2021, 331: 112948.

5  Liu, L., Wang, Z.-Y., Liu, Y.*, and Xu C*. (2021) An Immersive Virtual Reality System for Rodents in Behavioral and Neural Research. International Journal of Automation and Computing : 10.1007/s11633-021-1307-y.

6 Chen HS, Zhang XL, Yang RR, Wang GL, Zhu XY, Xu YF, et al. An intein-split transactivator for intersectional neural imaging and optogenetic manipulation. Nat Commun 2022, 13: 3605.

7 Zha X, Wang L, Jiao ZL, Yang RR, Xu C, Xu XH. VMHvl-projecting Vglut1+ neurons in the posterior amygdala gate territorial aggression. Cell Rep 2020, 31: 107517.

8 Chen AX, Yan JJ, Zhang W, Wang L, Yu ZX, Ding XJ, et al. Specific hypothalamic neurons required for sensing conspecific male cues relevant to inter-male aggression. Neuron 2020, 108: 763–774.e6.

9 Wang YT, Dai GY, Gu ZL, Liu GP, Tang K, Pan YH, et al. Accelerated evolution of an Lhx2 enhancer shapes mammalian social hierarchies. Cell Res 2020, 30: 408–420.

10 Babalian A, Eichenberger S, Bilella A, Girard F, Szabolcsi V, Roccaro D, et al. The orbitofrontal cortex projects to the parvafox nucleus of the ventrolateral hypothalamus and to its targets in the ventromedial periaqueductal grey matter. Brain Struct Funct 2019, 224: 293–314.

11 Krabbe S, Paradiso E, d'Aquin S, Bitterman Y, Courtin J, Xu C, et al. Adaptive disinhibitory gating by VIP interneurons permits associative learning. Nat Neurosci 2019, 22: 1834–1843.

12 Fadok JP, Krabbe S, Markovic M, Courtin J, Xu C, Massi L, et al. A competitive inhibitory circuit for selection of active and passive fear responses. Nature 2017, 542: 96–100.

13 Glangetas C, Massi L, Fois GR, Jalabert M, Girard D, Diana M, et al. NMDA-receptor-dependent plasticity in the bed nucleus of the stria terminalis triggers long-term anxiolysis. Nat Commun 2017, 8: 14456.

14 Xu C, Krabbe S, Gründemann J, Botta P, Fadok JP, Osakada F, et al. Distinct hippocampal pathways mediate dissociable roles of context in memory retrieval. Cell 2016, 167: 961–972.e16.

15 Botta P, Demmou L, Kasugai Y, Markovic M, Xu C, Fadok JP, et al. Regulating anxiety with extrasynaptic inhibition. Nat Neurosci 2015, 18: 1493–1500.

16 Wlodarczyk AI, Xu C, Song I, Doronin M, Wu YW, Walker MC, et al. Tonic GABAA conductance decreases membrane time constant and increases EPSP-spike precision in hippocampal pyramidal neurons. Front Neural Circuits 2013, 7: 205.

17 Yu Y, Xu C, Pan X, Ren H, Wang W, Meng X, et al. Identification and functional analysis of novel mutations of the CLCNKB gene in Chinese patients with classic Bartter syndrome. Clin Genet 2010, 77: 155–162.

18 Xu C, Zhao MX, Poo MM, Zhang XH. GABA(B) receptor activation mediates frequency-dependent plasticity of developing GABAergic synapses. Nat Neurosci 2008, 11: 1410–1418.