Neuroscience Bulletin协办由中国科学院脑科学与智能技术卓越创新中心举办的上海神经科学研讨会（Shanghai Neuroscience Seminar）。该系列研讨会每期都将邀请不同的国内外神经科学专家在线为大家带来精彩的学术报告。
2022年10月27日举办上海神经科学在线学术研讨会第10期。
人类是一种高度社会化的物种。人类的社会行为（social behavior）区别于其他行为的关键在于行为的产生中是否考虑到了另外一个人。而任何试图影响或考虑对方主观经验或意图的行为又被称为社会互动（social interaction）。社会认知（social cognition）是我们思考他人的方式。通过社会认知，我们了解他人的情绪、思想、意图和社会行为。然而，如何在人以及动物身上研究社会认知？并且又是如何做到可以在单个神经元水平进行研究？社会行为是奖赏驱动的。研究表明，前额叶皮层和杏仁核参与社会行为的调节，并与精神疾病的产生相关。前额叶皮层和杏仁核是如何根据奖赏信息做出决策并介导社会互动的？社会互动可分为语言沟通和非语言沟通。狨猴是最小的灵长类动物，它们的语音交流行为非常丰富。狨猴的社会结构组成类似于人类的家庭。如何通过狨猴来研究亲社会行为以及语音沟通的神经环路机制？
本期研讨会的主题是“Symposium on Social Behavior”，分别邀请到哈佛大学医学院的Ziv Williams教授、耶鲁大学的Steve Chang教授以及中国科学院脑科学与技术卓越创新中心（简称“脑智卓越中心”）的龚能研究员为大家带来精彩的报告！
本次报告由AiBrain神经科学新媒体平台提供直播技术支持，欢迎收看！
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会议详情
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报告人介绍
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Ziv Williams 教授
哈佛大学医学院
实验室主页：
https://zivwilliams.mgh.harvard.edu/
题目：
Studying Social Cognition in Animal Species and Humans
研究方向：
1. Human Cognitive Processing；
2. Primate Social Cognition；
3. Neural Restoration；
4. Network Modeling；
5. Nanotechnology.
学术成果（上下滑动查看）：
1. Li SW, Zeliger O, Strahs L, Báez-Mendoza R, Johnson LM, McDonald Wojciechowski A, et al. Frontal neurons driving competitive behaviour and ecology of social groups. Nature 2022, 603: 661–666.
2. Paulk AC, Kfir Y, Khanna AR, Mustroph ML, Trautmann EM, Soper DJ, et al. Large-scale neural recordings with single neuron resolution using Neuropixels probes in human cortex. Nat Neurosci 2022, 25: 252–263.
3. Beaulieu-Laroche L, Brown NJ, Hansen M, Toloza EHS, Sharma J, Williams ZM, et al. Allometric rules for mammalian cortical layer 5 neuron biophysics. Nature 2021, 600: 274–278.
4. Báez-Mendoza R, Mastrobattista EP, Wang AJ, Williams ZM. Social agent identity cells in the prefrontal cortex of interacting groups of Primates. Science 2021, 374: eabb4149.
5. Lee DK, Li SW, Bounni F, Friedman G, Jamali M, Strahs L, et al. Reduced sociability and social agency encoding in adult Shank3-mutant mice are restored through gene re-expression in real time. Nat Neurosci 2021, 24: 1243–1255.
6. Khanna AR, Williams ZM. Genes that give our brains their rhythms. Nat Neurosci 2021, 24: 455–456.
7. Jamali M, Grannan BL, Fedorenko E, Saxe R, Báez-Mendoza R, Williams ZM. Single-neuronal predictions of others' beliefs in humans. Nature 2021, 591: 610–614.
8. Jamali M, Grannan B, Haroush K, Moses ZB, Eskandar EN, Herrington T, et al. Dorsolateral prefrontal neurons mediate subjective decisions and their variation in humans. Nat Neurosci 2019, 22: 1010–1020.
9. Beaulieu-Laroche L, Toloza EHS, van der Goes MS, Lafourcade M, Barnagian D, Williams ZM, et al. Enhanced dendritic compartmentalization in human cortical neurons. Cell 2018, 175: 643–651.e14.
10. Lee DK, Fedorenko E, Simon MV, Curry WT, Nahed BV, Cahill DP, et al. Neural encoding and production of functional morphemes in the posterior temporal lobe. Nat Commun 2018, 9: 1877.
11. Quadrato G, Nguyen T, Macosko EZ, Sherwood JL, Min Yang S, Berger DR, et al. Cell diversity and network dynamics in photosensitive human brain organoids. Nature 2017, 545: 48–53.
12. Williams ZM. Good vibrations with deep brain stimulation. Nat Neurosci 2015, 18: 618–619.
13. Haroush K, Williams ZM. Neuronal prediction of opponent's behavior during cooperative social interchange in Primates. Cell 2015, 160: 1233–1245.
14. Shanechi MM, Hu RC, Williams ZM. A cortical-spinal prosthesis for targeted limb movement in paralysed primate avatars. Nat Commun 2014, 5: 3237.
15. Patel SR, Sheth SA, Martinez-Rubio C, Mian MK, Asaad WF, Gerrard JL, et al. Studying task-related activity of individual neurons in the human brain. Nat Protoc 2013, 8: 949–957.
16. Mian MK, Sheth SA, Patel SR, Spiliopoulos K, Eskandar EN, Williams ZM. Encoding of rules by neurons in the human dorsolateral prefrontal cortex. Cereb Cortex 2014, 24: 807–816.
17. Sheth SA, Mian MK, Patel SR, Asaad WF, Williams ZM, Dougherty DD, et al. Human dorsal anterior cingulate cortex neurons mediate ongoing behavioural adaptation. Nature 2012, 488: 218–221.
18. Shanechi MM, Hu RC, Powers M, Wornell GW, Brown EN, Williams ZM. Neural population partitioning and a concurrent brain-machine interface for sequential motor function. Nat Neurosci 2012, 15: 1715–1722.
19. Williams ZM, Eskandar EN. Selective enhancement of associative learning by microstimulation of the anterior caudate. Nat Neurosci 2006, 9: 562–568.
20. Williams ZM, Neimat JS, Cosgrove GR, Eskandar EN. Timing and direction selectivity of subthalamic and pallidal neurons in patients with Parkinson disease. Exp Brain Res 2005, 162: 407–416.
21. Williams ZM, Bush G, Rauch SL, Cosgrove GR, Eskandar EN. Human anterior cingulate neurons and the integration of monetary reward with motor responses. Nat Neurosci 2004, 7: 1370–1375.
22. Williams ZM, Elfar JC, Eskandar EN, Toth LJ, Assad JA. Parietal activity and the perceived direction of ambiguous apparent motion. Nat Neurosci 2003, 6: 616–623.
Steve Chang 教授
耶鲁大学
实验室主页：
https://changlab.yale.edu/welcome-lab
题目：
Prefrontal and Amygdalar Mechanisms of Primates Social Interaction
研究方向（上下滑动查看）：
Investigating how the brain computes social preferences and mediates prosocial and antisocial decisions can offer an ecologically valid and efficient way to understand the brain. In particular, studying how the brain computes social information during dynamic and contingent interactions will likely reveal novel insights into the neural mechanisms underlying social behavior. Elucidating these neural mechanisms will ultimately help treat social deficits in numerous psychiatric disorders. In addressing these issues, our laboratory focuses on how the prefrontal cortex and the amygdala signal social decisions and mediate social gaze dynamics. We apply both neurophysiological and neuropharmacological approaches during real-life social interactions as well as functional neuroimaging techniques in humans while they make value-based social decisions.
学术成果（上下滑动查看）：
1. Dal Monte O, Fan SQ, Fagan NA, Chu CCJ, Zhou MB, Putnam PT, et al. Widespread implementations of interactive social gaze neurons in the primate prefrontal-amygdala networks. Neuron 2022, 110: 2183–2197.e7.
2. Gangopadhyay P, Chawla M, dal Monte O, Chang SWC. Prefrontal-amygdala circuits in social decision-making. Nat Neurosci 2021, 24: 5–18.
3. Dal Monte O, Chu CCJ, Fagan NA, Chang SWC. Specialized medial prefrontal-amygdala coordination in other-regarding decision preference. Nat Neurosci 2020, 23: 565–574.
Lockwood PL, Apps MAJ, Chang SWC. Is there a ‘social’ brain? implementations and algorithms. Trends Cogn Sci 2020, 24: 802–813.
4. Basile BM, Schafroth JL, Karaskiewicz CL, Chang SWC, Murray EA. The anterior cingulate cortex is necessary for forming prosocial preferences from vicarious reinforcement in monkeys. PLoS Biol 2020, 18: e3000677.
5. Dal Monte O, Piva M, Anderson KM, Tringides M, Holmes AJ, Chang SWC. Oxytocin under opioid antagonism leads to supralinear enhancement of social attention. Pro Nat Aca Sci USA 2017, 114: 5247–5252.
6. Apps MAJ, Rushworth MFS, Chang SWC. The anterior cingulate gyrus and social cognition: Tracking the motivation of others. Neuron 2016, 90: 692–707.
7. Fan SQ, Weinberg-Wolf H, Piva M, dal Monte O, Chang SWC. Combinatorial oxytocin neuropharmacology in social cognition. Trends Cogn Sci 2020, 24: 8–12.
8. Piva M, Velnoskey K, Jia RN, Nair A, Levy I, Chang SW. The dorsomedial prefrontal cortex computes task-invariant relative subjective value for self and other. eLife 2019, 8: e44939.
9. Chang SWC. An emerging field of primate social neurophysiology: Current developments. eNeuro 2017, 4: ENEURO.0295–ENEURO.0217.2017.
10. Dal Monte O, Piva M, Morris JA, Chang SW. Live interaction distinctively shapes social gaze dynamics in rhesus macaques. J Neurophysiol 2016, 116: 1626–1643.
11. Chang SWC, Gariépy JF, Platt ML. Neuronal reference frames for social decisions in primate frontal cortex. Nat Neurosci 2013, 16: 243–250.
12. Chang SW, Barter JW, Ebitz RB, Watson KK, Platt ML. Inhaled oxytocin amplifies both vicarious reinforcement and self reinforcement in rhesus macaques (Macaca mulatta). Pro Nat Aca Sci USA 2012, 109: 959–964.
You can find more on their webpage.
龚能 研究员
脑智卓越中心
实验室主页：
http://www.cebsit.cas.cn/yjz/gongneng/yjfx/
题目：
Rules of Prosocial Behavior and Vocal Communication in Mamoset Monkeys
研究方向（上下滑动查看）：
意识、语言和共情等大脑的高级认知功能是人类社会行为的基础。对于高级认知功能的进化起源和神经机制的研究一直是神经科学领域的难点热点问题，是人类认识自我的最终挑战。非人灵长类动物在进化上与人类接近，具有与人类相似的大脑结构和功能，因而在研究高级认知功能上具有独特的优势。我们实验室的目标是建立研究高级认知功能的非人灵长类动物模型，并开展机制研究，从而帮助我们理解人类高级认知功能的进化起源和神经基础。
学术成果（上下滑动查看）：
1. Huang JF, Cheng XC, Zhang SK, Chang LT, Li XB, Liang ZF, et al. Having infants in the family group promotes altruistic behavior of marmoset monkeys. Curr Biol 2020, 30: 4047–4055.e3.
2. Zhang YJ, Huang JF, Gong N, Ling ZH, Hu Y. Automatic detection and classification of marmoset vocalizations using deep and recurrent neural networks. J Acoust Soc Am 2018, 144: 478.
3. Chang LT, Zhang SK, Poo MM, Gong N. Spontaneous expression of mirror self-recognition in monkeys after learning precise visual-proprioceptive association for mirror images. Proc Natl Acad Sci USA 2017, 114: 3258–3263.
4. Liu Z, Li X, Zhang JT, Cai YJ, Cheng TL, Cheng C, et al. Autism-like behaviours and germline transmission in transgenic monkeys overexpressing MeCP2. Nature 2016, 530: 98–102.
5. Chang LT, Fang Q, Zhang SK, Poo MM, Gong N. Mirror-induced self-directed behaviors in rhesus monkeys after visual-somatosensory training. Curr Biol 2015, 25: 212–217.
6. Zhao L, Gong N, Liu M, Pan XL, Sang SM, Sun XJ, et al. Beneficial synergistic effects of microdose lithium with pyrroloquinoline quinone in an Alzheimer's disease mouse model. Neurobiol Aging 2014, 35: 2736–2745.
7. Wang YW, Fang Q, Gong N. A modified light-dark box test for the common marmoset. Neurosci Bull 2014, 30: 394–400.
8. Wang YW, Fang Q, Gong N. Motor assessment of developing common marmosets. Neurosci Bull 2014, 30: 387–393.
9. Yu Z, Fang Q, Xiao X, Wang YZ, Cai YQ, Cao H, et al. GABA transporter-1 deficiency confers schizophrenia-like behavioral phenotypes. PLoS One 2013, 8: e69883.
10. Pan X, Gong N, Zhao J, Yu Z, Gu F, Chen J, et al. Powerful beneficial effects of benfotiamine on cognitive impairment and-amyloid deposition in amyloid precursor protein/presenilin-1 transgenic mice. Brain 2010, 133: 1342–1351.
11. Xu TL, Gong N. Glycine and glycine receptor signaling in hippocampal neurons: Diversity, function and regulation. Prog Neurobiol 2010, 91: 349–361.
12. Pan X, Gong N, Zhao J, Yu Z, Gu F, Chen J, et al. Powerful beneficial effects of benfotiamine on cognitive impairment and-amyloid deposition in amyloid precursor protein/presenilin-1 transgenic mice. Brain 2010, 133: 1342–1351.
13. Gong N, Zhang M, Zhang XB, Chen L, Sun GC, Xu TL. The aspirin metabolite salicylate enhances neuronal excitation in rat hippocampal CA1 area through reducing GABAergic inhibition. Neuropharmacology 2008, 54: 454–463.
14. Zhang LH, Gong N, Fei D, Xu L, Xu TL. Glycine uptake regulates hippocampal network activity via glycine receptor-mediated tonic inhibition. Neuropsychopharmacology 2008, 33: 701–711.
15. Zhang Z, Gong N, Wang W, Xu L, Xu TL. Bell-shaped D-serine actions on hippocampal long-term depression and spatial memory retrieval. Cereb Cortex 2008, 18: 2391–2401.
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直播路径
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直播时间：
北京时间：10月27日 9:00
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