「7月28日14:00直播」中科院神经所联合Neuroscience Bulletin衰老主题在线学术研讨会

由中国科学院脑科学与智能技术卓越创新中心举办、Neuroscience Bulletin协办的系列在线学术研讨会（Online Seminar Series），每期都将邀请不同的国内外神经科学专家在线为我们带来精彩的学术报告。

AiBrain神经科学新媒体将提供全程直播以及实时英文字幕，欢迎参与讨论！

2022年7月28日在线学术研讨会是该系列的第7期。迄今为止，可考证的人类最长寿记录为122岁。显而易见，衰老是我们生命过程的必经阶段。伴随衰老而来的是包括阿尔茨海默病、帕金森病等在内的神经退行性疾病以及诸如糖尿病、器官功能衰竭等的代谢性疾病。

然而，我们为什么会衰老呢？调控衰老的机制有哪些？衰老的多组学研究有哪些进展？免疫系统在衰老中发挥了哪些作用？我们能否干预衰老进程？能否防治伴随衰老而来的各种疾病？

本期研讨会的主题是“Symposium on Aging”，分别邀请到清华大学的王戈林教授、中国科学院动物研究所的刘光慧教授以及天津医科大学总医院神经内科的刘强教授为大家带来精彩的报告！

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讲座信息

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主持人介绍

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张洪钧研究员

博士，研究员。现任中国科学院脑科学和智能技术卓越创新中心生物节律与衰老疾病研究组组长。

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报告人介绍

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王戈林教授

清华大学

主要研究方向：

1、从系统调节 NAD 代谢的角度研究衰老生物学；

2、筛选和开发新的抗神经退行性疾病和抗癌的小分子药物，并利用这些小分子作为探针来揭示疾病的发病机理。

个人主页：

http://www.sps.tsinghua.edu.cn/cn/team/team/2016/1008/87.html

▽上下滑动浏览

1. Yao H, Liu M, Wang L, Zu Y, Wu C, Li C, et al. Discovery of small-molecule activators of nicotinamidephosphoribosyltransferase (NAMPT) and their preclinical neuroprotective activity. Cell Research. 2022. doi.org/10.1038/s41422-022-00651-9

2. Wang LB, Liu MH, Zu YM, Yao H, Wu C, Zhang RX, et al. Optimization of NAMPT activators to achieve in vivo neuroprotective efficacy. European Journal of Medicinal Chemistry. 2022. doi.org/10.1016/j.ejmech.2022.114260

3. Wang G, Han T, Nijhawan D, Theodoropoulos P, Naidoo J, Yadavalli S, et al. P7C3 neuroprotective chemicals function by activating the rate-limiting enzyme in NAD salvage. Cell 2014, 158: 1324-1334.

刘光慧教授

中国科学院动物研究所

主要研究方向：

1、人类衰老的遗传和表观遗传信息解码；

2、基于干细胞技术的人类疾病机理研究和精准治疗；
3、新型基因编辑手段和基因治疗技术的发展和应用。

个人主页：

http://sourcedb.ioz.cas.cn/zw/zjrc/201905/t20190514_5294619.html

▽上下滑动浏览

1. Ma S, Wang S, Ye Y, Ren J, Chen R, Li W, et al. Heterochronic parabiosis induces systemic rejuvenation and stem cell revitalization across aged tissues. Cell Stem Cell. 2022. 29:990-1005.e10.

2. Liu Z, Ji Q, Ren J, Yan P, Wu Z, Wang S, et al. Large-scale chromatin reorganization reactivates placenta-specific genes that drive cellular aging. Dev Cell. 2022. S1534-5807(22)00332-X

3. Zhao H, Ji Q, Wu Z, Wang S, Ren J, Yan K, et al. Destabilizing heterochromatin by APOE mediates senescence. Nat Aging. 2022. 2, 303–316

4. Liang C, Ke Q, Liu Z, Ren J, Zhang W, Hu J, et al. BMAL1 moonlighting as a gatekeeper for LINE1 repression and cellular senescence in primates. Nucleic Acids Res. 2022. 50:3323-3347.

5. Kang W, Jin T, Zhang T, Ma S, Yan H, Liu Z, et al. Regeneration Roadmap: database resources for regenerative biology. Nucleic Acids Res. 2022. 50(D1):D1085-D1090.

6. Liu ZP, Li W, Geng L, Sun L, Wang Q, Yu Y, et al. Cross-species metabolomic analysis identifies uridine as a potent regeneration promoting factor. Cell Discov. 2022. 1;8(1):6.

7. Shan H, Geng L, Jiang X, Song M, Wang J, Liu Z, et al. Large-scale chemical screen identifies gallic acid as a geroprotector for human stem cells. Protein Cell. 2022. doi: 10.1007/s13238-021-00872-5.

8. Hishida T, Yamamoto M, Hishida-Nozaki Y, Shao C, Huang L, Wang C, et al. In vivo partial cellular reprogramming enhances liver plasticity and regeneration. Cell Rep. 2022. 39(4):110730.

9. Wang W, Zheng Y, Sun S, Li W, Song M, Ji Q, et al. A genome-wide CRISPR-based screen identifies KAT7 as a senescence driver. Sci Transl Med. 2021.13: eabd2655.

You can find more on his webpage.

刘强教授

天津医科大学总医院神经内科

主要研究方向：

脑疾病的免疫机制和临床干预

▽上下滑动浏览

1. Shi K, Li H, Chang T, He W, Kong Y, Qi C, et al. Bone marrow hematopoiesis drives multiple sclerosis progression. Cell. 2022;185:2234.

2. Jin WN, Shi K, He W, Sun JH, Van Kaer L, Shi FD, Liu Q. Neuroblast senescence during normal brain aging augments natural killer cell cytotoxicity that impairs neurogenesis and cognition. Nat Neurosci. 2021;24:61.

Editorial highlight: Nat Neurosci. 2021;24:2: “Natural killers of cognition” by Valery Krizhanovsky.

Editor’s Choice: Sci Immunol. 2021;6:eabg3186: “Killing the buzz: NK cells in the aged brain” by Rachael A. Clark.

3. Shi SX, Shi KB, Liu Q. Brain injury instructs bone marrow cellular lineage to reduce neuroinflammation. Sci Transl Med. 2021;13:eabc7029. Sci Transl Med. 2021;13:

Cover story: “Nixing neuroinflammation”.

Editorial comment: “Promoting neuroimmune interaction after ICH”.

4. Li Z, Li M, Shi S, Yao N, Cheng X, Guo A, et al. Brain transforms natural killer cells that exacerbate brain edema after intracerebral hemorrhage. J Exp Med. 2020;217:e20200213.

5. Shi SX, Li YJ, Shi K, Wood K, Ducruet AF, Liu Q. IL (Interleukin)-15 bridges astrocyte-microglia crosstalk and exacerbates brain injury following intracerebral hemorrhage. Stroke. 2020;51:967.

6. Jin WN, Gonzales R, Feng Y, Wood K, Chai Z, Dong JF, et al. Brain ischemia induces diversified neuroantigen-specific T-cell responses that exacerbate brain injury. Stroke. 2018;49:1471.

7. Ren H, Kong Y, Liu Z, Zang D, Yang X, Wood K, et al. Selective NLRP3 (Pyrin Domain-Containing Protein 3) inflammasome inhibitor reduces brain injury after intracerebral hemorrhage. Stroke. 2018;49:184.

8. Liu Q*#, Jin WN#, Liu Y, Shi K, Sun H, Zhang F, et al. Brain ischemia suppresses immunity in the periphery and brain via different neurogenic innervations. Immunity. 2017; 46:474. #Co-first authors.

Editorial highlight: Immunity. 2017;46:340: “Disarming the killers: brain strikes on NK cells” by Sophie Ugolini.

9. Jin WN, Shi SX, Li Z, Li M, Wood K, Gonzales RJ, Liu Q. Depletion of microglia exacerbates post-ischemic inflammation and brain injury. J Cereb Blood Flow Metab. 2017;37:2224.

10. Liu Q*, Sanai N, Jin WN, La Cava A, Van Kaer L, Shi FD*. Neural stem cells sustain natural killer cells that dictate recovery from brain inflammation. Nat Neurosci. 2016;19:243. *Co-corresponding authors.

Editorial highlight: Nat Neurosci. 2016;19:176: “Natural killers in the brain's nursery” by Jonathan Kipnis.

此前AiBrain对刘强教授今年六月在Cell发布的文章进行了介绍，欢迎大家查看（点击图片即可跳转）：

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直播路径

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直播时间：

北京时间：7月28日 14:00

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http://www.medtion.com/meetingInfoLive.jspx?id=2357即可进入直播界面

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