今天为大家带来的是《Neurosurgery》（中文版）神经肿瘤分册第十期，由王毅教授编译，程宏伟教授审校的：“立体定向放射外科治疗肢端肥大症：一项国际多中心队列回顾性研究”摘要，欢迎阅读、分享。
原文：
Stereotactic Radiosurgery for Acromegaly: An International Multicenter Retrospective Cohort Study
原文作者：
Dale Ding, MD1 Gautam U. Mehta, MD2 Mohana Rao Patibandla, MBBS3 Cheng-Chia Lee, MD4 Roman Liscak, MD5 Hideyuki Kano, MD, PhD6 Fu-Yuan Pai, BA4 Mikulas Kosak, MD7 Nathaniel D. Sisterson, BA6 Roberto Martinez-Alvarez, MD, PhD8 Nuria Martinez-Moreno, MD, PhD8 David Mathieu, MD9 Inga S. Grills, MD10 Kevin Blas, MD10 Kuei Lee, MD, PhD10 Christopher P. Cifarelli, MD, PhD11 Gennadiy A. Katsevman, MD11 John Y.K. Lee, MD12 Brendan McShane, BS12 Douglas Kondziolka, MD13 L. Dade Lunsford, MD6 Mary Lee Vance, MD3,14 Jason P. Sheehan, MD, PhD3
作者单位：
1. Department of Neurosurgery, Barrow Neurological Institute, Phoenix, Arizona;
2. Department of Neurosurgery, MD Anderson Cancer Center, Houston, Texas;
3. Department of Neurosurgery, University of Virginia, Charlottesville, Virginia;
4. Department of Neurosurgery, Taipei Veterans General Hospital, Taipei, Taiwan;
5. Department of Stereotactic and Radiation Neurosurgery, Na Homolce Hospital, Prague, Czech Republic;
6. Department of Neurological Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania;
7. Department of Medicine, First Faculty of Medicine, Charles University, Prague, Czech Republic;
8. Department of Neurosurgery, Ruber Internacional Hospital, Madrid, Spain;
9. Division of Neurosurgery, Centre de recherche du CHUS, University of Sherbrooke, Sherbrooke, Quebec, Canada;
10. Department of Radiation Oncology, Beaumont Health System, Royal Oak, Michigan;
11. Department of Neurosurgery, West Virginia University, Morgantown, West Virginia;
12. Department of Neurosurgery, University of Pennsylvania, Philadelphia, Pennsylvania, USA;
13. Department of Neurosurgery, New York University Langone Medical Center, New York, New York;
14. Department of Medicine, University of Virginia, Charlottesville, Virginia.
编译：
王 毅
审校：
程宏伟
背景
目的
方法
收集并分析10家国际伽玛刀研究中心的肢端肥大症患者数据，进入研究的患者均接受了SRS治疗且内分泌随访的时间≥6个月。
结果
本队列研究纳入了371名患者，其内分泌平均随访时间为79个月。56%的患者在接受SRS治疗前停用了降IGF-1药物。SRS平均治疗范围为3.0cm³，边缘剂量为24.2Gy。内分泌学缓解率在治疗初期及第10年分别为69%和59%。SRS治疗后长期缓解平均时间为38个月。约9%的患者在最初的缓解后又出现了内分泌学指标的复发，平均复发时间为17个月。在SRS之前停用降低IGF-1药物是持续缓解的唯一独立预测因素（P=0.01）。SRS的副反应包括26%患者出现至少一种新的内分泌学异常，4%的患者出现≥1种颅神经损伤。
结论
SRS对于持续性及手术切除后复发的肢端肥大症有确切疗效。在接受SRS前停用降IGF-1药物有利于提高长期缓解率。
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