今日与大家分享的是《正海-妙术视界》第一百四十八期,由上海市第一人民医院神经外科主任楼美清教授带来的:“内镜经鼻斜坡切除侵犯脑干的肿瘤”,文末由著名颅底外科专家卢亦成教授、著名神经内镜专家张晓彪教授作出精彩点评,欢迎观看、分享。
楼美清教授:内镜经鼻斜坡切除侵犯脑干的肿瘤
楼美清 教授,上海市第一人民医院神经外科主任,医学博士,主任医师,博士生导师。
中华医学会上海市神经外科专委会常委,中国医师协会神经内镜专业委员会委员,中国医师协会微侵袭神经外科专委会委员,世界华人神经外科协会脊柱脊髓专家委员会副主委,中国医师协会脑血管病专业委员会委员,上海市抗癌协会神经肿瘤专业委员会副主委,中华医学会神经脊柱专业委员会委员,中国垂体瘤协作组委员。
从事神经外科工作27年,有高度娴熟扎实的显微镜和内镜神经外科技术操作功底, 在颅内肿瘤、脑血管病、脊椎等神经系统疾病手术中积累了约6000余例的丰富临床经验。
擅长:内镜、显微微创技术治疗垂体瘤、听神经瘤、脑干等各类复杂颅底肿瘤,面瘫、偏瘫患者神经功能修复。微创治疗三叉神经痛、面肌痉挛、椎间盘突出等神经痛疾病。
专家门诊时间:周一下午、周三下午
IMCC精品特需预约门诊: 周四上午
Clinical Presentation
22y, Female headache , double Vision for 4 m;
Examination:GCS 15 scores;abducens nerve palsy
MRI Images:Reveals occupying lesions in pre-pon cistern, tumor with a upper clivus extension imbedding into brainstem from anterior. Part of clivus bone is erosion.
Pre-op CT scan
Pre-op CT scan
Pre-op CT Contrast
Pre-op MRI Contrast
Pre-op MRI Contrast
Pre-op MRI Contrast
Initial Diagnosis:
Chordoma ? Meningioma?
Surgical approaches:
1. Kawase approach : Tumor embedding into brainstem, brain tissue cover the tumor, part of cortical-spinal tract maybe damaged irreversibly. Part of clivus bone erosed, it is difficult to drill away by this approach, maybe part of the tumor be remained.
2. Endoscopic Transnasal approach: Invaded clivus bone can be removed easily, tumor embedding into brainstem can be removed directly and safely, damaging to brainstem tissue reduced maximally.
Endoscopic Transnasal approach was chosen.
• Make nasal septum pedicle mucosa flap
• Drill sphenoidal anterior wall
• Sellar Floor and Clivus
• Sellar Floor bone removed and dura appear, Part of clivus dura evaded
• Remove rightside Posterior Clinoid Process
• Remove leftside Posterior Clinoid Process
• Open Clivus Dura
• Debulking Tumor
• After debulking, dissecting tumor margin
• Tumor embedding brainstem appeared
• Tumor in CPA, with 30° angle rigid
• After tumor removal,brainstem
• The defective area was sealed with artificial dura sutured to the remaining dura
• Sellar floor reconstruction was performed using layers of fat, fascia, and nasal turbinate tissues
Post-op CT
Post-op MRI with contrast
Post-op MRI with contrast
Post-op MRI
Pathological Result
Chordoma
Immunohistological Results:CK(+),VIM (+) ,PR (-),S-100 (+),GFAP,EMA (+),Ki67 (15%+),Desmin(-),Calponin(-),ER(-)。
General condition is good.
No CSF fistula, double Vision improved.
专家点评 著名颅底外科专家卢亦成教授点评: PPT和手术视频都已看过,做的非常好。由于我对内镜了解不多,更无颅底方面内镜的实践经验,所以很难把你的精髓总结得恰到好处。看了这个材料,学到很多,能够与时俱进,敢于进取,善于总结,就一定能在神经外科的路上再创辉煌! 著名神经内镜专家张晓彪教授点评: 对于这例年轻女性侵犯脑干的斜坡脊索瘤,楼美清教授选择了内镜经鼻斜坡入路是最佳策略。术中从制作带蒂中隔瓣、保留重建骨片、充分暴露、精细分离并全切肿瘤、直到多层重建,每一步都精心计划和细致处理,最后病人恢复良好。整个过程将内镜经鼻斜坡入路教科书式实施完成,术中操作规范,结果良好。这一例手术的成功实施,说明只要选好适应症、规范化手术,就可以获得满意的疗效,同时降低并发症的发生,真正体现内镜导航微创的优势!